走進(jìn)哈獸研
綜合新聞
科研進(jìn)展
科研成果
人才招聘
辦公系統(tǒng)
掃一掃 關(guān)注我
1、個(gè)人簡歷
祁小樂，男，博士，研究員，博士生導(dǎo)師。中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所禽免疫抑制病創(chuàng)新團(tuán)隊(duì)、動(dòng)物疫病防控全國重點(diǎn)實(shí)驗(yàn)室、世界動(dòng)物衛(wèi)生組織（WOAH）傳染性法氏囊病參考實(shí)驗(yàn)室骨干專家。國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目首席科學(xué)家、全國青年崗位能手、黑龍江省高層次人才(B類)、中國農(nóng)科院農(nóng)科英才；中國家禽疾病診療分委會(huì)秘書長、中國禽病學(xué)分會(huì)理事、中國獸醫(yī)公共衛(wèi)生學(xué)分會(huì)理事；科技部國家科技專家?guī)鞂＜?、教育部學(xué)位中心專家、國家自然基金委同行評議專家；中國免疫學(xué)青年學(xué)者獎(jiǎng)、中國畜牧獸醫(yī)學(xué)會(huì)獎(jiǎng)、黑龍江省青年科技獎(jiǎng)、中國農(nóng)科院建院60周年卓越奉獻(xiàn)獎(jiǎng)獲得者；中國家禽、Viruses等期刊編委或編輯。
主要從事傳染性法氏囊?。?/span>IBD）等禽免疫抑制病和種源性疫病研究，率先制定了IBDV新的基因分型方法，首次鑒定了IBDV新型變異株新疫情的流行，闡明了我國IBDV流行新態(tài)勢；解析了迄今分辨率最高的IBDV粒子結(jié)構(gòu)；率先建立了IBDV新型反向遺傳研究平臺(tái)，揭示了IBDV致病和遺傳變異的分子機(jī)制；創(chuàng)制了IBD等新型疫苗和檢測技術(shù)，獲發(fā)明專利20余項(xiàng)，獲國家新獸藥證書4項(xiàng)，制定國家和行業(yè)標(biāo)準(zhǔn)4項(xiàng)。主持國家項(xiàng)目10余項(xiàng)；以第1或通訊作者在Science Bulletin、mBio等發(fā)表論文60余篇；參編專著7部；獲中華農(nóng)業(yè)科技獎(jiǎng)一等獎(jiǎng)等成果獎(jiǎng)8項(xiàng)。已培養(yǎng)研究生20余人（包括哈獸研首批博士留學(xué)生），學(xué)生多次獲得國家獎(jiǎng)學(xué)金等榮譽(yù)，畢業(yè)生均在學(xué)術(shù)單位、政府部門和龍頭企業(yè)肩負(fù)重要職責(zé)。
2、聯(lián)系方式
電話：0451-51051692（辦公室）；13845044863（手機(jī)）
郵箱：qixiaole@caas.cn
通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號
3、教育經(jīng)歷
1997.09-2001.06 河南農(nóng)業(yè)大學(xué) 獸醫(yī)專業(yè) 學(xué)士
2001.09-2004.06 河南農(nóng)業(yè)大學(xué) 預(yù)防獸醫(yī)專業(yè) 碩士
2004.09-2007.06 中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 預(yù)防獸醫(yī)專業(yè) 博士
2012.09 農(nóng)業(yè)部高級專業(yè)技術(shù)人員理論業(yè)務(wù)培訓(xùn)班
4、工作經(jīng)歷
2007.07-2009.11 中國農(nóng)科院哈爾濱獸醫(yī)研究所 助理研究員
2012.01-2012.04 法國食品環(huán)境及勞動(dòng)衛(wèi)生署Ploufragan研究所 高級訪問學(xué)者
2009.12-2017.12 中國農(nóng)科院哈爾濱獸醫(yī)研究所 副研究員
2018.01-至今 中國農(nóng)科院哈爾濱獸醫(yī)研究所 研究員
5、承擔(dān)主要項(xiàng)目
傳染性法氏囊病病毒新型變異株免疫逃匿的分子機(jī)制（32072852），國家自然科學(xué)基金面上項(xiàng)目，2021-2024，58萬元，主持；
雞傳染性法氏囊病病毒細(xì)胞嗜性及致病性變異的分子基礎(chǔ)（30901083），國家自然科學(xué)基金青年基金，2010-2012，20萬元，主持；
禽白血病病毒復(fù)制早期關(guān)鍵宿主因子發(fā)掘及其作用機(jī)制研究（32230105），國家自然科學(xué)基金重點(diǎn)項(xiàng)目， 2023-2027，274萬元，主要承擔(dān)人（第2）；
傳染性法氏囊病強(qiáng)、弱毒侵染宿主細(xì)胞的分子機(jī)制（31430087），國家自然科學(xué)基金重點(diǎn)項(xiàng)目，2015-2019，318萬元，主要承擔(dān)人（第2）；
家禽主要傳染病綜合防控研究及國際科技合作平臺(tái)建設(shè)（2016YFE0203200），十三五國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目，2017-2020，839萬元，主持；
畜禽重要免疫抑制性病原的免疫逃逸機(jī)制（2022YFD1800305-1），十四五國家重點(diǎn)研發(fā)計(jì)劃子課題，2022-2025，65萬元，主持；
傳染性法氏囊病及馬立克氏病等禽免疫抑制病免疫防控新技術(shù)研究（2017YFD0500704），十三五國家重點(diǎn)研發(fā)計(jì)劃子課題，2017-2020，53萬元，主持；
中國雞傳染性法氏囊病病毒基因及抗原變異的生物學(xué)意義（2011008007），中法蔡元培交流合作項(xiàng)目，2011-2013，17萬元，主持；
雞傳染性法氏囊病病毒超強(qiáng)毒株致弱的主要分子基礎(chǔ)（2080440921），中國博士后科學(xué)基金，2009-2011，3萬元，主持；
禽雙RNA病毒新型變異株遺傳變異及免疫逃匿的分子機(jī)制（ZD2020C006），黑龍江省自然科學(xué)基金重點(diǎn)項(xiàng)目，2020-2023，50萬元，主持。
6、代表論文與著作
Niu XX, Han JZ, Huang MM, Wang GD, Zhang YL, Zhang WY, Yu HB, Xu MM, Li K, Gao L, Wang SY, Chen YT, Cui HY, Zhang YP, Liu CJ, Wang XM, Gao YL*, Qi XL*. Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner. mBio, 2024, 15(3): e0343323.
Wang GD, Jiang N, Yu HB, Niu XX, Huang MM, Zhang YL, Zhang WY, Han JZ, Xu MM, Liu RH, Wu ZW, Han JZ, Wang SY, Gao L, Cui HY, Zhang YP, Chen YT, Gao YL*, Qi XL*. Loop PDE of viral capsid protein is involved in immune escape of the emerging novel variant infectious bursal disease virus. Veterinary Microbiology, 2024, 293: 110094.
Jiang N, Wang GD, Zhang WY, Wang YL, Niu XX, Huang MM, Gao L, Li K, Cui HY, Liu CJ, Zhang YP, Bao KY, Wang SY, Chen YT, Wang XM, Gao YL*, Qi XL*. A single mutation of VP2 is responsible for the lethality and antigenicity differences between novel variant and very virulent IBDV strains. Transboundary and Emerging Diseases, 2023, 6684304.
Zhang WY, Wang XM, Gao YL*, Qi XL*. The over-40-years-epidemic of infectious bursal disease virus in China. Viruses, 2022, 14(10): 2253.
Bao KY#, Qi XL#, Li Y, Gong MM, Wang XM*, Zhu P*. Cryo-EM structures of infectious bursal disease virus with different virulence provide insights on their assembly and invasion. Science Bulletin, 2022, 67: 646-654.
Fan LJ, Wang YL, Jiang N, Gao YL, Niu XX, Zhang WY, Huang MM, Bao KY, Liu AJ, Wang SY, Gao L, Li K, Cui HY, Pan Q, Liu CJ, Zhang YP, Wang XM, Qi XL*. Residues 318 and 323 in capsid protein are involved in immune circumvention of the epidemic atypical infection of infectious bursal disease virus. Frontiers Microbiology, 2022, 13: 909252.
Jiang N, Wang Y, Zhang W, Niu X, Huang M, Gao Y, Liu A, Gao L, Li K, Pan Q, Liu C, Zhang Y, Cui H, Wang X, Qi X*. Genotyping and molecular characterization of infectious bursal disease virus identi?ed in important poultry-raising areas of China during 2019 and 2020. Frontiers in Veterinary Science, 2021, 8: 759861.
Wang YL, Fan LJ, Jiang N, Gao L, Li K, Gao YL, Liu CJ, Cui HY, Pan Q, Zhang YP, Wang XM*, Qi XL*. An improved scheme for infectious bursal disease virus genotype classification based on both genome-segments A and B. Journal of Integrative Agriculture, 2021, 20(5): 1372-1381.
Wang YL, Jiang N, Fan LJ, Niu XX, Zhang WY, Huang MM, Gao L, Li K, Gao YL, Liu CJ, Cui HY, Liu AJ, Pan Q, Zhang YP, Wang XM, Qi XL*. Identification and pathogenicity evaluation of a novel reassortant infectious bursal disease virus (Genotype A2dB3). Viruses, 2021, 13(9): 1682.
Jiang N, Wang YL, Zhang WY, Niu XX, Gao YL, Gao L, Li K, Cui HY, Liu AJ, Pan Q, Liu CJ, Zhang YP, Wang XM, Qi XL*. Naturally occurring mutated infectious bursal disease virus of genotype A8B1 associated with bursa damage in China. Virus Research, 2021, 302: 198498.
Wang YL, Jiang N, Fan LJ, Gao L, Li K, Gao YL, Niu XX, Zhang WY, Cui HY, Liu AJ, Pan Q, Liu CJ, Zhang YP, Wang XM*, Qi XL*. Development of a viral‐like particle candidate vaccine against novel variant infectious bursal disease virus. Vaccines, 2021, 9(2):142.
Fan LJ, Wang YL, Jiang N, Chen MG, Gao L, Li K, Gao YL, Cui HY, Pan Q, Liu CJ, Zhang YP, Wang XM*, Qi XL*. Novel variant infectious bursal disease virus suppresses Newcastle disease vaccination in broiler and layer chickens. Poultry Science, 2020, 99:6542-6548.
Fan LJ, Wang YL, Jiang N, Gao L, Li K, Gao YL, Cui HY, Pan Q, Liu CJ, Zhang YP, Wang XM*, Qi XL*. A reassortment vaccine candidate of the novel variant infectious bursal disease virus. Veterinary Microbiology, 2020, 251: 108905.
Fan LJ, Wu TT, Wang YL, Hussain A, Jiang N, Gao L, Li K, Gao YL, Liu CJ, Cui HY, Pan Q, Zhang YP, Wang XM, Qi XL*. Novel variants of infectious bursal disease virus can severely damage the bursa of fabricius of immunized chickens. Veterinary Microbiology, 2020, 240: 108507.
Wang YL, Fan LJ, Jiang N, Gao L, Li K, Gao YL, Liu CJ, Cui HY , Pan Q, Zhang YP, Wang XM, Qi XL*. Naturally occurring cell-adapted classic strain of infectious bursal disease virus. Veterinary Microbiology, 2020, 243: 108620.
Wu TT, Wang YL, Li H, Fan LJ, Jiang N, Gao L, Li K, Gao YL, Liu CJ, Cui HY, Pan Q, Zhang YP, Wang XM*, Qi XL*. Naturally occurring homologous recombination between novel variant infectious bursal disease virus and intermediate vaccine strain. Veterinary Microbiology, 2020, 245: 108700.
Fan LJ, Wu TT, Hussain A, Gao YL, Zeng XY, Wang YL, Gao L, Li K, Wang YQ, Liu CJ, Cui HY, Pan Q, Zhang YP, Liu YF, He HJ, Wang XM*, Qi XL*. Novel variant strains of infectious bursal disease virus isolated in China. Veterinary Microbiology, 2019, 230: 212-220. (*通訊作者)
Zhang LZ, Li H, Chen YM, Gao X, Lu Z, Gao L, Wang YQ, Gao YL, Gao HL, Liu CJ, Cui HY, Zhang YP, Pan Q, Qi XL*, Wang XM*. The down-regulation of casein kinase 1 alpha as a host defense response against infectious bursal disease virus infection. Virology, 2017, 512: 211-221.
Chen YM, Zhang LZ, Gao L, Wang N, Lu Z, Gao X, Wang YQ, Li K, Gao YL, Cui HY, Gao HL, Liu CJ, Zhang YP, Qi XL*, Wang XM*. Ribosomal protein L4 interacts with viral VP3 and regulates the replication of infectious bursal disease virus. Virus Research, 2016，211: 73-78.
Qi XL, Gao X, Lu Z, Zhang LZ, Wang YQ, Gao L, Gao YL, Li K, Gao HL, Liu CJ, Cui HY, Zhang YP, Wang XM*. A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus. SCIENCE CHINA Life Sciences, 2016（59）: 717-723.
Lu Z, Zhang LZ, Wang N, Chen YM, Gao L, Wang YQ, Gao HL, Gao YL, Li K, Qi XL*, Wang XM*. Naturally occurring reassortant infectious bursal disease virus in northern China. Virus Research. 2015, 203: 92-95.
Wang N. Zhang LZ, Chen YM, Lu Z, Gao L, Wang YQ, Gao YL, Gao HL, Cui HY, Li K, Liu CJ, Zhang YP, Qi XL*, Wang XM*. Cyclophilin A interacts with viral VP4 and inhibits the replication of infectious bursal disease virus. BioMed Research International, 2015, 719454.
Zhang LZ, Ren XG, Chen YM, Gao YL, Wang N, Lu Z, Gao L, Qin LT, Wang YQ, Gao HL, Li K, Jiang LL, Cui HY, Liu CJ, Zhang YP, Qi XL*, Wang XM*. Chondroitin sulphate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus via interaction with the capsid protein VP2. Viruses, 2015, 7(3): 1474-91.
Deng XY, Hu F, Qi XL*, Gao L, Li K, Gao HL, Gao YL, Wang YQ, Shen N, Hua YP*, Wang XM*. Construction and characterization of the recombinant reticuloendotheliosis virus expressing enhanced green fluorescent protein. Archive Virology, 2015, 160(9): 2231-2235.
Qi XL, Lu Z, Wang N, Chen YM, Zhang LZ, Gao L, Li K, Ren XG, Wang YQ, Gao HL, Gao YL, Nicolas E, Wang XM*. Analysis of the function of D279N mutation of VP2 of infectious bursal disease virus. Journal of Integrative Agriculture, 2015, 14(2): 2618-2625.
Ren XG, Zhang LZ, Gao YL, Gao HL, Wang YQ, Liu CJ, Cui HY, Zhang YP, Jiang LL, Qi XL*, Wang XM*. Binding chicken Anx2 is beneficial for infection with infectious bursal disease virus. Virus Research, 2015，210: 232-240.
Hu F, Zhao Y, Qi XL*, Cui HY, Gao YL, Gao HL, Liu CJ, Wang YQ, Zhang YP, Li K, Wang XM*, Wang YF*. Soluble expression and enzymatic activity evaluation of protease from reticuloendotheliosis virus. Protein Expression and Purification. 2015, 114: 64-70.
Qi XL, Chen YM, Ren XG, Zhang LZ, Gao L, Wang N, Qin LT, Wang YQ, Gao YL, Wang XM*. A reassortment vaccine candidate as the improved formulation to induce protection against very virulent infectious bursal disease virus. Vaccine, 2014, 32: 1436-1443.
Qi XL, Zhang LZ, Chen YM, Gao L, Wu G, Qin LT, Wang YQ, Ren XG, Gao YL, Gao HL, Wang XM*. Mutations of residues 249 and 256 in VP2 are involved in the replication and virulence of infectious bursal disease virus. Plos One, 2013, 8(7):e70982.
Deng XY#, Qi XL#, Wu G, Gao YL, Qin LT, Wang YQ, Gao HL, Wang XM*. Construction and characterization of the infectious clone of reticuloendotheliosis virus carrying a genetic marker. Virus Research, 2012, 167(2):146-151.
Wang YQ#, Qi XL#, Kang ZH, Yu F, Qin LT, Gao HL, Gao YL, Wang XM*. A single amino acid in the C-terminus of VP3 protein influences the replication of attenuated infectious bursal disease virus in vitro and in vivo. Antiviral Research, 2010, 87: 223-229.
Deng XY#, Qi XL#, Gao YL, Wang YQ, Qin LT, Gao HL, Gao L, Wang XM*. Development of a loop-mediated isothermal amplification method for rapid detection of reticuloendotheliosis virus. Journal of Virological Methods, 2010, 168: 82-86. (*共同第1作者)
Qi XL, Gao HL, Gao YL, Qin LT, Wang YQ, Gao L, Wang XM*. Naturally occurring mutations at residues 253 and 284 in VP2 contribute to the cell tropism and virulence of very virulent infectious bursal disease. Antiviral Research, 2009, 84: 225-233.
Qi XL, Gao YL, Gao HL, Deng XY, Bu ZG, Fu CY, Wang XY, Wang XM*. An improved method for infectious bursal disease virus rescue using RNA polymerase II system. Journal of Virological Methods, 2007, 142: 81-88.
祁小樂 參譯，《獸醫(yī)微生物學(xué)》第3版，中國農(nóng)業(yè)出版社，2021.
祁小樂 參譯，《現(xiàn)代馬病診療學(xué)》第7版，中國農(nóng)業(yè)出版社，2020.
祁小樂 參譯，《獸醫(yī)病毒學(xué)》第4版，中國農(nóng)業(yè)出版社，2015.
祁小樂 參編，《獸醫(yī)微生物學(xué)》第2版，中國農(nóng)業(yè)出版社，2014.
祁小樂 參編，《動(dòng)物病毒反向遺傳學(xué)》，科學(xué)出版社，第1版（2009），第2版（2014）.
祁小樂 參編，《動(dòng)物基因工程疫苗原理與方法》，化學(xué)工業(yè)出版社，2009.
7、獲得主要獎(jiǎng)勵(lì)
雞傳染性法氏囊病變異的分子機(jī)制研究及系列疫苗研發(fā)，大北農(nóng)科技獎(jiǎng)特等獎(jiǎng)（科技部備案），排名第2. 大北農(nóng)科技有限公司. 2011.
禽白血病綜合防控關(guān)鍵技術(shù)創(chuàng)制與應(yīng)用，中國農(nóng)業(yè)科學(xué)院杰出科技創(chuàng)新獎(jiǎng)，排名第3. 中國農(nóng)業(yè)科學(xué)院. 2023.
雞傳染性法氏囊病超強(qiáng)毒的細(xì)胞適應(yīng)株及其應(yīng)用，中國專利優(yōu)秀獎(jiǎng)，排名第3. 國家知識(shí)產(chǎn)權(quán)局. 2018年.
禽白血病防控關(guān)鍵技術(shù)的研制與應(yīng)用，大北農(nóng)科技獎(jiǎng)二等獎(jiǎng)（科技部備案），排名第3. 大北農(nóng)科技有限公司. 2022.
禽重要免疫抑制病防控關(guān)鍵技術(shù)創(chuàng)制與應(yīng)用，黑龍江省科技進(jìn)步一等獎(jiǎng)，排名第4. 黑龍江省政府. 2018.
中國農(nóng)業(yè)科學(xué)院成果轉(zhuǎn)化優(yōu)秀團(tuán)隊(duì)獎(jiǎng)，排名第4. 中國農(nóng)業(yè)科學(xué)院. 2022.
雞傳染性法氏囊病超強(qiáng)毒變異機(jī)制及防制技術(shù)研究與應(yīng)用，黑龍江省科技進(jìn)步一等獎(jiǎng)，排名第5. 黑龍江省政府. 2008.
雞傳染性法氏囊病超強(qiáng)毒變異機(jī)制及防制技術(shù)研究與應(yīng)用，中華農(nóng)業(yè)科技獎(jiǎng)一等獎(jiǎng)，排名第5. 農(nóng)業(yè)部. 2009.
新型禽用疫苗及診斷試劑研究團(tuán)隊(duì)，中華農(nóng)業(yè)科技優(yōu)秀創(chuàng)新團(tuán)隊(duì)獎(jiǎng)一等獎(jiǎng)，排名第6. 農(nóng)業(yè)部. 2013.
禽白血病綜合防控技術(shù)及應(yīng)用，哈爾濱市科技進(jìn)步二等獎(jiǎng)，排名第9. 哈爾濱市政府. 2016年.
8、主要專利和標(biāo)準(zhǔn)
祁小樂，王笑梅，高玉龍，高立，崔紅玉，李凱，劉長軍，潘青，張艷萍.抗IBDV VP2蛋白的單克隆抗體組合及其在鑒別檢測IBDV中的用途. 專利授權(quán)號：ZL202011466765.6.，中國，2022.12.
祁小樂，王笑梅，高玉龍，高立，李凱，崔紅玉，劉長軍，潘青，張艷萍，劉愛晶. 雞傳染性法氏囊病病毒新型變異株亞單位疫苗、其制備方法及應(yīng)用. 專利授權(quán)號：ZL202011473614.3.，中國，2022.12.
祁小樂，王笑梅，高玉龍，高立，李凱，崔紅玉，劉長軍，潘青. 一株自然適應(yīng)體外細(xì)胞培養(yǎng)的雞傳染性法氏囊病病毒經(jīng)典株及其應(yīng)用，專利授權(quán)號：ZL202010090643.5.，中國，2021.8.
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