1、個人簡歷
鄧國華，男，博士，三級研究員，博士生導師，動物流感防控與基礎研究創(chuàng)新團隊骨干一級，從事禽流感監(jiān)測與流行病學研究工作，多年來一直主持、承擔和參與多項禽流感病毒基礎研究以及應用基礎研究項目，包括國家973項目、國家科技支撐項目、國家重點研發(fā)計劃和國家自然科學基金項目等，發(fā)表SCI及中文核心期刊論文100余篇。先后獲得國家科技進步一等獎、國家技術發(fā)明二等獎、國家自然科學獎二等獎、黑龍江省自然科學一等獎、科技進步一等獎、哈爾濱市科技進步獎二等獎、黑龍江省青年“五四”獎章等獎勵和榮譽。目前兼任揚州大學客座教授和兼職碩士研究生導師，中國畜牧獸醫(yī)學會禽病學分會理事，第六屆農(nóng)業(yè)轉(zhuǎn)基因生物安全委員會委員，第四屆全國動物防疫專家委員會委員。
2、聯(lián)系方式
研究方向：動物傳染病及其病原分子流行病學
聯(lián)系電話：0451-51051806
郵箱：dengguohua01@caas.cn
通訊地址：哈爾濱市香坊區(qū)哈平路678號
3、教育經(jīng)歷
1990/09-1995/06 華中農(nóng)業(yè)大學 獸醫(yī)專業(yè) 學士
1999/09-2001/03 東北農(nóng)業(yè)大學 預防獸醫(yī)學專業(yè) 碩士
2001/09-2004/06 中國農(nóng)業(yè)大學 預防獸醫(yī)學專業(yè) 博士
4、工作經(jīng)歷
1995/07-1999/12 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 研究實習員
2000/01-2004/12 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 助理研究員
2005/01-2011/12 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 副研究員
2007/03-2008/03 英國牛津大學 訪問學者
2012/01-今 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 研究員
5、承擔的課題
1. 國家重點研發(fā)計劃項目課題“動物流感病毒監(jiān)測及進化研究”，2021YFD1800201,2021.05-2025.12,1145萬，課題負責人；
2. 國家自然科學基金面上項目“2.3.4.4分支H5亞型禽流感病毒抗原差異的分子基礎”，32172837，2022.01-2025.12,58萬，項目負責人；
3. 農(nóng)業(yè)農(nóng)村部行業(yè)專項“奶牛禽流感病毒感染及禽流感防治措施評估”，“禽流感病毒遺傳進化”，每年148.24萬，項目負責人；
4. 國家自然科學基金地區(qū)聯(lián)合基金項目“西北地區(qū)禽流感病毒生態(tài)分布及其傳播機制研究”，U23A20243，103.2萬，項目參與人。
6、代表論文與著作
1. Yan C#, Shi J#, Cui P#, Chen Y, Wang C, Wang Y, Miao J, Zhang Y, Kong H, Zeng X, Tian G, Li C, Suzuki Y, Deng G.*, Chen H.* 2025. Characterization of emerging H3N3 avian influenza viruses in poultry in China. Emerg Microbes Infect 14:2509748.
2. Cui P. #, Shi J. #, Yan C. #, Wang C, Zhang Y, Zhang Y, Xing X, Chen Y, Zhang J, Liu L, Zeng X, Tian G, Li C, Suzuki Y, Deng G.*, Chen H.* 2023. Analysis of avian influenza A (H3N8) viruses in poultry and their zoonotic potential, China, September 2021 to May 2022. Euro Surveill: 2023 Oct;28(41):2200871. doi: 10.2807/1560-7917.ES.2023.28.41.2200871.
3. Hou Y.*, Deng G.*, Cui P., Zeng X., Li B., Wang D., He X., Yan C., Zhang Y., Li J., Ma J., Li Y., Wang X., Tian G., Kong H., Tang l., Yasuo Suzuki, Shi J. *, Chen H. *, Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination. Emerg Microbes Infect. 2024 Dec;13(1):2343912. doi: 10.1080/22221751.2024.2343912.
4. Xing X., Shi J., Cui P., Yan C., Zhang Y., Zhang Y., Wang C., Chen Y., Zeng X., Tian G., Liu L., Guan Y., Li C., Yasuo Suzuki, Deng G.*, Chen H.*, Evolution and biological characterization of H5N1 influenza viruses bearing the clade 2.3.2.1 hemagglutinin gene. Emerg Microbes Infect. 2024 Dec;13(1):2284294. doi: 10.1080/22221751.2023.2284294.
5. Zhang Y., Shi J., Cui P., Zhang Y., Chen Y., Hou Y., Liu L., Jiang Y., Guan Y., Chen H., Kong H.*, Deng G.*, Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021. J Med Virol. 2023 Feb;95(2):e28476. doi: 10.1002/jmv.28476.
6. Zhang Y., Cui P., Shi J., Chen Y., Zeng X., Jiang Y., Tian G., Li C., Chen H., Kong H.*, Deng G.*, Key Amino Acid Residues That Determine the Antigenic Properties of Highly Pathogenic H5 Influenza Viruses Bearing the Clade 2.3.4.4 Hemagglutinin Gene. Viruses. 2023 Nov 13;15(11):2249. doi: 10.3390/v15112249.
7. Zhang Y., Cui P., Shi J., Zeng X., Jiang Y., Chen Y., Zhang J., Wang C., Wang Y., Tian G., Chen H., Kong H.*, Deng G.*, A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes. NPJ Vaccines. 2024 Aug 19;9(1):152. doi: 10.1038/s41541-024-00947-4.
8. Gu W.#, Shi J.#, Cui P.#, Yan C., Zhang y., Wang C., Zhang Y., Xing X., Zeng X., Liu L., Tian G., Yasuo Suzuki, Li C., Deng G.*, Chen H.*. Novel H5N6 reassortants bearing the clade 2.3.4.4b HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China. Emerg Microbes Infect. 2022 Dec;11(1):1174-1185. doi: 10.1080 /22221751. 2022.2063076.
9. Cui P.#, Shi J,.#, Wang C.#, Zhang Y., Xing X., Kong H., Yan C., Zeng X., Liu L., Tian G., Li C., Deng G.*, Chen H.*. Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China. Emerg Microbes Infect. 2022 Dec;11(1):1693-1704. doi: 10.1080/22221751.2022.2088407.
10. Cui P. #, Zeng X. #, Li X. #, Li Y. #, Shi J. #, Zhao C, Qu Z, Wang Y, Guo J, Gu W, Ma Q, Zhang Y, Lin W, Li M, Tian J, Wang D, Xing X, Liu Y, Pan S, Zhang Y, Bao H, Liu L, Tian G, Li C, Deng G*, Chen H*. Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China. Sci China Life Sci. 2021 Nov 8. doi: 10.1007/s11427-021-2025-y.
11. Cui J., Cui P., Shi J., Fan w, Xing X., Gu W., Zhang Y., Zhang Y., Zeng X., Jiang Y., Chen P., Yang H., Chen Y., Liu J., Liu L., Tian G, Lu Y., Chen H, Li C. *, Deng G. *. Continued evolution of H6 avian influenza viruses isolated from farms in China between 2014 and 2018, Transboundary and Emerging Diseases. First published: 30 June 2021, https://doi.org/10.1111/tbed.14212.
12. Kong X., Guan L., Shi J., Kong H., Zhang Y., Zeng X., Tian G., Liu L., Li C., Yoshihiro Kawaoka, Deng G. *, Chen H. *. A single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice. Emerg Microbes Infect. 2021 Dec; 10(1): 2052-2061. doi: 10.1080/22221751.2021.1997340.
13. Yin X.#, Deng G.#, Zeng X.#, Cui P., Hou Y. , Liu Y., Fang J., Pan S., Wang D., Chen X., Zhang Y., Wang X., Tian G., Li Y., Chen Y., Liu L., Yasuo Suzuki, Guan Y., Li C., Shi J. *, Chen H. *. Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China. PLoS Pathog. 2021 Apr 27;17(4):e1009561. doi: 10.1371/journal.ppat.1009561.
14. Guan L., Shi J., Kong X., Ma S., Zhang Y., Yin X., He X., Liu L., Suzuki Y., Li C., Deng G.*, Chen H.*. H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets. Emerg Microbes Infect. 2019;8(1):1280-1290. doi: 10.1080/22221751.2019.1660590.
15. Li X, Cui P, Zeng X, Jiang Y, Li Y, Yang J, Pan Y, Gao X, Zhao C, Wang J, Wang K, Deng G*, Guo J*. Characterization of avian influenza H5N3 reassortants isolated from migratory waterfowl and domestic ducks in China from 2015 to 2018. Transbound Emerg Dis. 2019 Nov; 66(6):2605-2610. doi: 10.1111/tbed.13324. Epub 2019Aug 26.
16. Shi J. #, Deng G. #, Ma S., Zeng X., Yin X., Li M., Zhang B., Cui P., Chen Y., Yang H., Wan X., Liu l., Chen P., Jiang Y., Guan Y., Liu J., Gu W., Han S., Chen H.. Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017. Cell Host &Microbe. 2018, Volume 24, Issue 4, 10 October, Pages 558-568.e7.
17. Shi J. #, Deng G. #, Kong H., Gu C., Ma S., Yin X., Zeng X, Cui P, Chen Y, Yang H, Wan X, Wang X, Liu L, Chen P, Jiang Y, Liu J, Guan Y, Suzuki Y, Li M, Qu Z, Guan L, Zang J, Gu W, Han S, Song Y, Hu Y, Wang Z, Gu L, Yang W, Liang L, Bao H, Tian G, Li Y, Qiao C, Jiang L, Li C, Bu Z, Chen H*. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Research. 2017 Dec;27(12):1409-1421. doi: 10.1038/cr.2017.
18. Cui P, Deng G*, Shi J, Kong H, Liu L, Guan Y, Suzuki Y, Chen H*. 2016. New influenza A(H7N7) viruses detected in live poultry markets in China. Virology. 2016, 499:165-169.
19. Liang L. #, Deng G. #, Shi J., Wang S., Zhang Q., Kong H., Gu C., Guan Y., Suzuki Y., Li Y., Jiang Y., Tian G., Liu L., Li C.*, Chen H.*. Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China. Journal of Virology. 2015.90:1455-1469.
20. Deng G.#, Shi J. #, Wang J., Kong H., Cui P., Zhang F., Tan D., Suzuki Y., Liu L., Jiang Y., Guan Y., Chen H*. Genetics, Receptor Binding, and Virulence in Mice of H10N8 Influenza Viruses Isolated from Ducks and Chickens in Live Poultry Markets in China. Journal of Virology. 2015. 89:6506-6510.
21. Shi J., Deng G., Zeng X., Kong H., Wang X., Lu K., Wang X., Mu G., Xu X., Cui P., Bao H., Tian G., Chen H*. Novel influenza A(H7N2) virus in chickens, Jilin province, China, 2014. Emerging Infectious Disease. 2014. 20:1719-1722.
22. Wang G. #, Deng G. #, Shi J., Luo W., Zhang G., Zhang Q., Liu L., Jiang Y., Li C., Sriwilaijaroen N., Hiramatsu H., Suzuki Y., Kawaoka Y., Chen H*. H6 influenza viruses pose a potential threat to human health. Journal of Virology. 2014. 88:3953-3964.
23. Zhang Q. #, Shi J. #, Deng G. #, Guo J. #, Zeng X. #, He X., Kong H., Gu C., Li X., Liu J., Wang G., Chen Y., Liu L., Liang L., Li Y., Fan J., Wang J., Li W., Guan L., Li Q., Yang H., Chen P., Jiang L., Guan Y., Xin X., Jiang Y., Tian G., Wang X., Qiao C., Li C., Bu Z., Chen H*. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science. 2013. 341:410-414.
24. Deng G. #, Tan D. #, Shi J., Cui P., Jiang Y., Liu L., Tian G., Kawaoka Y., Li C.*, Chen H.*. Complex reassortment of multiple subtypes of avian influenza viruses in domestic ducks at the dongting lake region of china. Journal of Virology. 2013. 87:9452-9462.
25. Ge J., Deng G., Wen Z., Tian G., Wang Y., Shi J., Wang X., Li Y., Hu S., Jiang Y., Yang C., Yu K., Bu Z.*, Chen H.*. Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. Journal of Virology. 2007. 81:150-158.
26. Chen H*, Deng G., Li Z., Tian G., Li Y., Jiao P., Zhang L., Liu Z., Webster RG., Yu K. The evolution of H5N1 influenza viruses in ducks in Southern China. Proc. Natl. Acad. Sci. USA. 2004.101:10452-10457.
8、專利
1. H5-Re11血凝素蛋白單克隆抗體及其抗原表位的應用，ZL 2024 1 0768077.7，鄧國華，崔鵬飛，陳化蘭，孔暉暉，施建忠，王秀榮;
2. 一種廣譜性識別N9亞型禽流感病毒神經(jīng)氨酸酶蛋白的單克隆抗體及其應用，中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所，授權， 2020100645011，鄧國華，崔鵬飛，陳化蘭，施建忠；
3. 一種識別N6亞型禽流感病毒神經(jīng)氨酸酶蛋白的單克隆抗體及其應用，中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所，授權，2020100667951， 鄧國華，崔鵬飛，陳化蘭，施建忠。
9、獲得獎勵
1. 流感病毒跨種感染人及傳播能力研究，國家自然科學獎二等獎，陳化蘭，施建忠，鄧國華，楊煥良，李雁冰，2019年12月18日；
2. 動物流感病毒跨種傳播能力研究，黑龍江省自然科學獎一等獎，陳化蘭，施建忠，鄧國華，楊煥良，李雁冰，2018年;
3. 動物流感病毒引起人流感大流行的潛力及其遺傳機制，中國農(nóng)業(yè)科學院杰出科技創(chuàng)新獎，陳化蘭、施建忠、鄧國華、李雁冰、李呈軍、曾顯營、劉麗玲、姜永萍、何希君、田國彬、關云濤、柳金雄、陳普成、陳艷、楊煥良，2015年;
4. 禽流感病毒進化、跨種感染及致病力分子機制研究，國家自然科學獎二等獎，陳化蘭，于康震，鄧國華，周繼勇，李澤軍，2013年;
5. H5N1亞型禽流感病毒進化、跨宿主感染及致病力分子機制研究，黑龍江省自然科學獎一等獎，陳化蘭、鄧國華、李雁冰、姜永萍、田國彬，2009年;
6. 禽流感、新城疫重組二聯(lián)活疫苗，國家技術發(fā)明獎二等獎，陳化蘭，步志高，葛金英，田國彬，李雁冰，鄧國華；2007年；H5亞型禽流感滅活疫苗的研制與應用，國家科學技術進步一等獎，于康震、陳化蘭、田國彬、辛朝安、唐秀英、廖明、張?zhí)K華、李雁冰、馮菊艷、李曉成、羅開健、施建忠、喬傳玲、姜永萍、鄧國華，2005年；
7. 于康震禽流感病毒重組核蛋白瓊擴抗原的研制與應用，黑龍江省科學技術進步一等獎，王秀榮、鄧國華、陳化蘭、楊林、田國彬、郭昭林、姜永萍、喬傳玲、孫建宏，2004年。
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