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孫明霞,博士,副研究員。主要研究方向?yàn)樨i繁殖與呼吸綜合征病毒、豬圓環(huán)病毒和豬偽狂犬病毒等免疫抑制性疾病致病機(jī)制研究及新型疫苗和檢測(cè)方法的研發(fā)。主持國(guó)家自然科學(xué)基金青年基金項(xiàng)目1項(xiàng),黑龍江省自然科學(xué)面上項(xiàng)目1項(xiàng),承擔(dān)“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃等項(xiàng)目。NPJ Vaccines, Vaccines, Transboundary and Emerging Diseases, International Journal of Biological Macromolecules, Viruses等雜志審稿人。發(fā)表SCI論文共48篇,其中以第一或通訊作者(包含共同)在Autophagy, Journal of Nanobiotechnology, International Journal of Biological Macromolecules和Veterinary Microbiology等雜志上發(fā)表文章12篇。作為主要執(zhí)行人獲得中國(guó)發(fā)明專(zhuān)利8項(xiàng),獲得新獸藥生產(chǎn)批號(hào)1項(xiàng)。
1、聯(lián)系方式
電話(huà):0451-51051768
郵箱:sunmingxia@caas.cn
通訊地址:黑龍江省哈爾濱市香坊區(qū)哈平路678號(hào),150069
2、教育經(jīng)歷
2008.09-2013.06 南京農(nóng)業(yè)大學(xué),預(yù)防獸醫(yī)學(xué),碩博
2004.09-2008.06 山東農(nóng)業(yè)大學(xué),動(dòng)物醫(yī)學(xué),學(xué)士
3、工作經(jīng)歷
2025.01-至今 中國(guó)農(nóng)科院哈爾濱獸醫(yī)研究所,副研究員
2013.07-2024.12 中國(guó)農(nóng)科院哈爾濱獸醫(yī)研究所,助理研究員
4、承擔(dān)項(xiàng)目
1). 國(guó)家青年科學(xué)基金,細(xì)胞自噬在偽狂犬病復(fù)制感染中的作用(C010802,2015-2017),24萬(wàn)元,主持
2). 黑龍江省自然科學(xué)基金,豬偽狂犬病毒調(diào)控自噬參與IFN先天免疫反應(yīng)研究(QC2018030, 2018-2022),6萬(wàn)元,主持
3). “十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃,重要?jiǎng)游锊≡腿诵蠊不疾】焖贆z測(cè)新技術(shù)研究(2021YFF0703300,2021-2024),300萬(wàn)元,子課題主持
4). 非洲豬瘟ELISA抗體檢測(cè)試劑盒的研制(20220304, 2021-2024),100萬(wàn)元,主持
5). 中國(guó)農(nóng)業(yè)科學(xué)院基本科研業(yè)務(wù)費(fèi)專(zhuān)項(xiàng)基金,重要豬病病毒納米抗體研究(1610302020006,2020-2022),40萬(wàn)元,主持
6). 中國(guó)農(nóng)業(yè)科學(xué)院基本科研業(yè)務(wù)費(fèi)專(zhuān)項(xiàng)基金,豬繁殖與呼吸綜合征病毒流行病學(xué)調(diào)查(1610302024007,2024-2026),36萬(wàn)元,主持
5、代表論文與著作
1). Su SB#, Sun MX#, Wang HW#, Tang YD, Chen J, Shi XQ, Cai S, Zhou HR, Yang W, Zhang N, Yang YB, Wang SJ, Zhao K, Zhang HL, Tian ZJ, Cai XH, Lu Y, Meng FD*, An TQ*. Nanobody-based bioPROTAC for viral proteins degradation provides a broad-spectrum antiviral strategy for porcine Arterivirus. J Nanobiotech. 2026, doi: 10.1186/s12951-026-04348-8.
2). Sun M, Cao D, Zhao M, Zhu X, Sun Y, Wang Q, Zhang H, Yang Y, Tian X, Wang H, Cai X*, An T*. Nanobody-based competitive enzymelinked immunosorbent assay for detecting antibodies of porcine reproductive and respiratory syndrome virus. Int J Biol Macromol. 2025, 312:144248.
3). Xia R#, Sun M#, Lu Y, Wang N, Zhang A, Guo C, Xu Z*, Cai X*, He Y*. Cryo-EM structure of a nanobody-bound heliorhodopsin. Biochem Biophys Res Commun. 2025, 750:151398.
4). Sun M#, Sun Y#, Yang Y#, Zhao M, Cao D, Zhang M, Xia D, Wang T, Gao Y, Wang S, Wang H, Cai X*, An T*. Multivalent nanobody-based sandwich enzyme-linked immunosorbent assay for sensitive detection of porcine reproductive and respiratory syndrome virus. Int J Biol Macromol. 2024, 258:128896.
5). Qi X, Fang Z, Meng L, Xiang X, Ju Y, Cai X, An T, Sun M*, Wang H*. The C3d-fused Porcine circovirus type 2d virus-like particle induced early and enhanced immune response and protected pigs against challenge. Vet Microbiol. 2024, 299:110305.
6). Zhou H#, Sun M#, Su S#, Meng L, Yang W, Yang L, Shi X, Li X, Wang H, Ma H, Cai X, Tang YD*, An T*, Meng F*. Identification of a linear B-cell epitope on the "puff" loop of the Senecavirus A VP2 protein involved in receptor binding. Front Microbiol. 2024, 15:1387309.
7). Jia M#, Sun M#, Tang YD, Zhang YY, Wang H, Cai X*, Meng F*. Senecavirus A Entry Into Host Cells Is Dependent on the Cholesterol-Mediated Endocytic Pathway. Front Vet Sci. 2022, 9:840655.
8). Sun M, Wang S, Fang Z, Zhao M, Gao Y, An T, Tu Y*, Wang H*, Cai X*. A Sandwich ELISA for Quality Control of PCV2 Virus-like Particles Vaccine. Vaccines (Basel). 2022, 10(12):2175.
9). Sun M#, Hou L#, Song H, Lyu C, Tang YD, Qin L, Liu Y, Wang S, Meng F*, Cai X*. The relationship between autophagy and apoptosis during pseudorabies virus infection. Front Vet Sci. 2022, 9:1064433.
10). Zhang YY#, Sun MX#, Lian Y#, Wang TY, Jia MY, Leng C, Chen M, Bai YZ, Meng F*, Cai XH*, Tang YD*. CRISPR-Cas13d Exhibits Robust Antiviral Activity Against Seneca Valley Virus. Front Microbiol. 2022, 13:835040.
11). Wang TY#, Sun MX#, Zhang HL, Wang G, Zhan G, Tian ZJ, Cai XH, Su C*, Tang YD*. Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus. Front Microbiol. 2021, 12:693799.
12). Wang TY#, Yang YL#, Feng C#, Sun MX, Peng JM, Tian ZJ*, Tang YD*, Cai XH*. Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65. Viruses. 2020, 12(1):51.
13). Sun M, Hou L, Tang YD, Liu Y, Wang S, Wang J, Shen N, An T, Tian Z, Cai X*. Pseudorabies virus infection inhibits autophagy in permissive cells in vitro. Sci Rep. 2017, 7:39964.
14). Tang YD, Liu JT, Wang TY, Sun MX, Tian ZJ, Cai XH*. CRISPR/Cas9-mediated multiple single guide RNAs potently abrogate pseudorabies virus replication. Arch Virol. 2017, 162(12):3881–3886.
15). Tang YD#, Liu JT#, Wang TY#, An TQ, Sun MX, Wang SJ, Fang QQ, Hou LL, Tian ZJ, Cai XH*. Live attenuated pseudorabies virus developed using the CRISPR/Cas9 system. Virus Res. 2016, 225:33–39.
16). Wang Y, Li JR, Sun MX, Ni B, Huan C, Huang L, Li C, Fan HJ, Ren XF*, Mao X*. Triggering unfolded protein response by 2-Deoxy-D-glucose inhibits porcine epidemic diarrhea virus propagation. Antiviral Res. 2014, 106:33–41.
17). Sun MX, Huang L, Wang R, Yu YL, Li C, Li PP, Hu XC, Hao HP, Ishag HA, Mao X*. Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication. Autophagy. 2012, 8(10):1434–47.
6、專(zhuān)利
1). 孫明霞,安同慶,孫悅,楊勇博。一種用于檢測(cè)PRRSV抗原的納米抗體對(duì)試劑盒及其應(yīng)用,ZL202210382554.7
2). 蔡雪輝,孫明霞,涂亞斌,王淑杰。識(shí)別PCV2病毒樣顆粒的單克隆抗體及其在定性及定量檢測(cè)PCV病毒樣顆粒中的作用,ZL201811261025.1
3). 王海偉,孫明霞,安同慶,蔡雪輝。豬圓環(huán)病毒2d型佐劑嵌合病毒樣顆粒疫苗及其制備方法,ZL202410370650.9
4). 孟凡丹,孫明霞,安同慶,蔡雪輝,湯艷東,蘇世博。靶向降解PRRSV關(guān)鍵復(fù)制酶的生物型蛋白降解靶向嵌合體及其應(yīng)用,ZL202310342828.4
5). 蔡雪輝,劉永剛,孫明霞,宋歡。豬繁殖與呼吸綜合征病毒Nsp2蛋白納米抗體及應(yīng)用,ZL201911157547.1
6). 涂亞斌,蔡雪輝,王剛,孫明霞。一種豬圓環(huán)病毒2b、2d型二價(jià)病毒樣顆粒疫苗及其制備方法和應(yīng)用,ZL202010780803.9
7). 涂亞斌,蔡雪輝,王剛,孫明霞。一種優(yōu)化后的豬圓環(huán)病毒3型衣殼蛋白基因及其在制備病毒樣顆粒中的應(yīng)用,ZL201910863646.5
8). 孟凡丹,安同慶,蔡雪輝,孫明霞,湯艷東,王海偉,周函蓉,盧宇,陳瑾。一種抗A型塞內(nèi)卡病毒的單克隆抗體以及抗原表位及應(yīng)用,ZL202311839446.9
7、獲得獎(jiǎng)勵(lì)
1). 豬繁殖與呼吸綜合征防控創(chuàng)新團(tuán)隊(duì);中華農(nóng)業(yè)科技獎(jiǎng)優(yōu)秀創(chuàng)新團(tuán)隊(duì)成果一等獎(jiǎng);2015年
2). 優(yōu)秀博士國(guó)家獎(jiǎng)學(xué)金;2013年
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